in 1928, with a thesis entitled Contribution to the theory of aerodynamic lift.
In 1928, Carafoli returned to Bucharest, where he joined the faculty at the Polytechnic University, and founded the Aerodynamics chair; later in 1936 he was promoted to full professor.
It was here that he built the first wind tunnel in South-Eastern Europe, and elaborated some of the theory on which calculations of wing profiles of supersonic aircraft are based.From 1930 to 1937 Carafoli worked at Industria Aeronautica Româna in Brasov.
A prototype was flown in 1931 by Captain Romeo Popescu, in an attempt at breaking the flight airspeed record, but the plane crashed, and the pilot lost his life.
Carafoli also designed the IAR 14 and IAR 15 aircraft, and later in 1937 initiated the development of the legendary IAR 80 fighter aircraft, at the urging of Prime Minister Armand Calinescu.In 1948, he was elected to the Romanian Academy.
In 1949 he became director of the Institute of Applied Mechanics of the Academy.
Carafoli was President of the International Astronautical Federation from 1968 to 1970.
In 1971, he reorganized, along with Henri Coanda, the Department of Aeronautical Engineering of the Polytechnic University of Bucharest, spinning it off from the Department of Mechanical Engineering.
Carafoli was awarded the Louis Breguet Prize (Paris,1927), the Gauss Medal, and the Apollo 11 Medal (1971).