Jean de Villiers (born 24 February 1981 in Paarl) is a former South African rugby union player.
He started his career at wing, but played most of his career as an inside centre.
De Villiers previously played for Western Province in the Currie Cup, the Stormers in Super Rugby, Leicester Tigers in Premiership Rugby and internationally for South Africa, for whom he was named captain in June 2012.