He is known for his history paintings of biblical and mythological subjects and portraits.
Wishing to contribute to the revival of painting in Flanders, he took his inspiration from the classical traditions of the 16th century and drew inspiration from Raphael.
He was thus a promoter of Neoclassicism in Flemish art.
He was a teacher and director of the Academy of Fine Arts of Antwerp.
Lens was court painter to the governor-general of the Austrian Netherlands and settled in Brussels where he married.