Francis de Lorraine II, Prince of Joinville, Duke of Guise, Duke of Aumale (French: François de Lorraine, duc de Guise; 17 February 1519 – 24 February 1563), was a French general and politician.
A prominent leader during the Italian War of 1551–1559 and French Wars of Religion, he was assassinated during the siege of Orleans in 1563.