After his death at Paris in 1825, his position at the Charenton was filled by Jean-Etienne-Dominique Esquirol.One of his famous patients at the Charenton was Donatien Alphonse François de Sade (1740–1814), better known as Marquis de Sade, who spent the last eleven years of his life incarcerated at the asylum.
Royer-Collard protested against de Sade's imprisonment at the Charenton, believing him to be sane, and asked that he be placed in a conventional prison.