In 1857, she took in children from the Washington County Infirmary, thus organizing the first children's home in the state of Ohio.Ewing taught school in Ohio before becoming a missionary among the Choctaw.
Ten years later, upon her return to Ohio, she founded a home for destitute children.
Through her efforts, the Ohio Legislature passed a bill in Columbus, which entitled every county to establish a children's home.
Ewing also authored a comprehensive historical report on the origin and growth of the children's home movement in Washington County.