Samuel Edmund Sewall (1799-1888) was an American lawyer, abolitionist, and suffragist.
He was one of the founders of the Massachusetts Anti-Slavery Society in 1831, lent his legal expertise to the Underground Railroad, and served a term in the Massachusetts Senate as a Free-Soiler.
Sewall was involved in several notable cases involving refugees from slavery, including George Latimer, Shadrach Minkins, Thomas Sims, Eliza Small, and Polly Ann Bates.
He also worked to advance women's legal rights in Massachusetts.
He was a descendant of the Puritan judge Samuel Sewall.