Mutsuko Miki (?? ??, Miki Mutsuko, 31 July 1917 – 31 July 2012) was a Japanese activist who advocated on behalf of pacifism, official compensation for comfort women, and improved Japan–North Korea relations.
She was the widow of former Japanese Prime Minister Takeo Miki.
Miki served as the wife of the Prime Minister of Japan, or First Lady, during her husband's two-year tenure from 1974–76.