Samantha Paxinos (born February 25, 1988) is a Botswana swimmer, who specialized in sprint freestyle events.
She became one of the first ever Botswana swimmers, alongside John Kamyuka, to compete at the 2008 Summer Olympics, and the first female to carry the nation's flag in the opening ceremony.
At the games she swam in heat three, but fell behind Olivia Aya Nakitanda of Uganda by more than half a second, failing to advance to the semifinals.