Charles-Jérémie Coulombe (October 23, 1846 – December 1, 1938) was a physician and political figure in Quebec.
He represented Maskinongé in the House of Commons of Canada from 1887 to 1891 as a Conservative member.
He was born in St-Cuthbert, Canada East, and educated at the college in L'Assomption.
In 1879, he married Marie Noémi Bernier.
He served as a major in the militia.
Coulombe was an unsuccessful candidate for a seat in the House of Commons in 1884.
His attempts at reelection in 1891 and 1896 were unsuccessful.