His other comics included La Famille Fenouillard (probably the first French comic, 1889); Le Sapeur Camember (1890–1896); Les Malices de Plick et Plock (1893–1904); and Le Baron de Cramoisy (1899).
Colomb's works were comic sketches exploring the quirks of his title characters.
Images to him were more vital than words in communicating with children (the dialogue and Colomb's editorial remarks were always outside the picture frame).
His frames have been said to anticipate the "visual grammar" of movies and television.Colomb retired as Deputy Director of the Sorbonne's botanical laboratory.
Novelist Marcel Proust was a student of Colomb in his youth, and seems to have taken an interest in botany from him—Proust's À la recherche du temps perdu (In Search of Lost Time) presents botanical knowledge and speculation to such an extent that botany "constitutes an alternative lens through which the human world of the novel can be viewed."