Landgravine Auguste Fredericka of Hesse-Homburg (full German name: Auguste Friederike, Landgräfin von Hessen-Homburg; 28 November 1776, Bad Homburg vor der Höhe, Landgraviate of Hesse-Homburg, Holy Roman Empire – 1 April 1871, Ludwigslust, Grand Duchy of Mecklenburg-Schwerin), was a member of the House of Hesse and a Landgravine of Hesse-Homburg by birth.
Through her marriage she was also a member of the House of Mecklenburg and Hereditary Grand Duchess of Mecklenburg-Schwerin.
She was the sixth child and fourth daughter of Frederick V, Landgrave of Hesse-Homburg and his wife Landgravine Caroline of Hesse-Darmstadt, in turn daughter of Louis IX, Landgrave of Hesse-Darmstadt.