César Henri Guillaume de La Luzerne (23 February 1737, Paris – 24 March 1799, château de Bernau, near Linz), seigneur de Beuzeville et de Rilly, baron de Chambon, was a French politician and soldier, rising to Lieutenant général des armées and naval minister.
He was the son of César-Antoine de La Luzerne, comte de Beuzeville (died 1755) and Marie-Elisabeth de Lamoignon de Blancmesnil (1716-1758).