Sam Byibesho (born 25 April 1964) is a Ugandan teacher, public administrator and politician.
He is the elected Member of Parliament for Kisoro Municipality and a representative for National Resistance Movement (NRM), the ruling political party in Uganda.
He is a member of the Local Government Accounts Committee, the Committee on Public Service and Local Government and; the NRM Parliamentary Caucus in the 10th Parliament of Uganda.
Byibesho formerly served as the mayor of Kisoro Town Council from 2002 up until 2016 when he became a legislator.
He is the former head teacher of Mubuga Primary School and previously worked as a Grade III teacher from 1991 to 1996.
He is also the NRM chairperson for his constituency, Kisoro Municipality.