Frans Kaisiepo (10 October 1921 – 10 April 1979) was a Papuan politician and Indonesian nationalist.
He served as the fourth Governor of Papua Province.
In 1993, Kaisiepo was posthumously declared a National Hero of Indonesia (Indonesian: Pahlawan Nasional Indonesia) for his lifelong efforts to unite West Irian with Indonesia.
As the representative of Papua province, he was involved in the Malino Conference, where the formation of the United States of Indonesia was discussed.