He met his first wife artist Mary Hiester Reid at the Pennsylvania Academy and remained with her until her death in 1921.
He also studied at the Julian, with Jean-Joseph Benjamin-Constant, and at the Colarossi Academies in Paris, and the Prado in Madrid (1888–89).
He made a number of study trips to Europe, during which he visited France, Italy, Spain and Portugal.
It was during this time that Reid turned from portraiture to genre, as in The Foreclosure of the Mortgage (1893), making his name with narrative pictures.
Reid brought Parisian Academy precision to emotional genre paintings of Ontario.
He was elected to the Royal Canadian Academy of Arts in 1889, and was principal of the Central Ontario School of Art and Design (later OCAD University) 1912-18.
He also did murals and private and public commissions, including one for Toronto's Third City Hall.
In 1922, he married fellow artist Mary E.
Wrinch..
George Agnew Reid died in 1947, leaving behind a body of work that often depicts scenes from his rural Ontario upbringing, with much of his work now found in public and private collections.