Louise Borgia (17 May 1500 – 1553) was a French noblewoman and Duchess of Valentinois, having succeeded to the title upon the death of her father Cesare Borgia, Duke of Valentinois, in 1507 when she was almost seven years old.
She was also Dame de Chalus, a title she inherited from her mother Charlotte of Albret.
She was a member of the Third Order of Saint Dominic.