After a season on loan at Blackburn Rovers, he moved to Wigan Athletic for £2 million in 2010, where he won the FA Cup in 2013.
After totalling 14 goals in 122 Premier League matches, he was released following Wigan's relegation to the Championship in 2013.
He then moved to Werder Bremen in Germany, spending two seasons there, before making a controversial switch to rivals Schalke 04.Di Santo has represented the Argentina national football team on three occasions.
He was nicknamed 'Crespito' (Little Crespo) after Chelsea's former Argentinian striker Hernán Crespo.