He set up practice first at Montreal and then at Saint-Eustache.
In 1809, he married Marie-Marguerite Gagnier, the daughter of the local notary at Saint-Eustache.
Labrie served as surgeon for the militia during the War of 1812.
He founded two schools, one for girls and one for boys, in his parish.
In 1827, he was elected to the Legislative Assembly of Lower Canada for York, as a supporter of the parti patriote.
He was elected for the new riding of Deux-Montagnes in 1830 after York was split up.
He died of pneumonia at Saint-Eustache in 1831 while still in office.
Labrie had written but not completed a history of Canada, which was deposited for safe-keeping in the library of Jean-Joseph Girouard.