In a career spanning more than three decades, Youssef's films have encompassed many themes and genres.
For several audiences, his films were an early prediction for 2010/2011 Arab uprisings.
In his films, Youssef has addressed the issues of authoritarianism, lack social justice, poverty, religious intolerance, corruption, restrictions on the freedom of thoughts and opinion, and the sexual violence in the Egyptian and the Arab communities.
As a result, he has been targeted by tens of judicial prosecutions and political harassments, motivated by different governments, over decades.
Recently, He became a member of the Egyptian Parliament since November 2015.