He is a specialist in Religion, Arts, Sociobiology, and the Upper Palaeolithic times of Europe and Central Asia.
In the book Speaking Australopithecus (written together with the philologist Francesco Benozzo) he confirms from the archaeological point of view Benozzo's hypothesis that human language appeared with Australopithecus, between 4 and 3 million years ago.Otte is one of the leading advocates of the Paleolithic Continuity Theory, which states that Indo-European languages originated in Europe and have existed there since Paleolithic TOMES.
He first advocated that theory in work published in 1995.