Marie Philibert Constant Sappey (1810 – 15 March 1896) was a French anatomist born in Cernon, near the city of Bourg-en-Bresse.
He studied medicine at the University of Paris, earning his degree in 1843.
In 1868 he succeeded Jean-François Jarjavay (1815–1868) as chair of anatomy, a position he held until 1886.
Sappey was a highly regarded anatomist remembered for his research of the lymphatic system.
In 1874 he published an anatomical atlas that included a detailed study of cutaneous lymphatic drainage.
He was married to Antoinette Clotilde Dumas who was a scientific illustrator.
She illustrated some of his publications.
He devised a procedure to define and delineate the lymphatic system by injecting mercury into the skin of a cadaver in order to properly view the individual lymphatic vessels.
Anatomist Henri Rouvière (1876-1952) continued Sappey's anatomical work of the human lymphatic system.