Michel-Siméon Delisle (September 27, 1856 – October 11, 1931) was a Canadian merchant and politician.
Born in Pointe-aux-Trembles, Portneuf County, Canada East, the son of Albert Delisle and Dina Bertrand, Delisle was educated in Quebec City.
A merchant, he was Mayor of Portneuf for five years.
He was first elected to the House of Commons of Canada at the general elections of 1900 and he was re-elected in 1904, 1908, 1911, 1917, 1925, and 1926.
A Liberal, he served for almost 30 years for the riding of Portneuf.