Luis Medina Cantalejo (born 1 March 1964) is a retired Spanish football referee.
Professionally, Medina Cantalejo is a sports assessor who lives in Tomares, west of Seville.
He was one of the few officials allowed to officiate the domestic clashes between Real Madrid and Barcelona.
His first experience as an international referee came on 4 September 2004, between Turkey and Georgia, in a preliminary qualifier for the 2006 FIFA World Cup.