Initially she fell in love with Philippe de Constant, a cousin, but due to local law was unable to marry him.
Instead, at 28 she married Étienne d’Aubonne, who died five years later.
Jonathan Polier de Saint-Germain, sgr de Corcelles-le-Jorat, lieutenant baillival de Lausanne, became her second husband in 1767.
The couple wintered in Lausanne, summering at the château de Corcelles-le-Jorat.
Polier de Corcelles is noted as a pastellist by Isabelle de Charrière in some of her letters; she is also known for having decorated the private theater of her cousin the marquis de Langallerie.