Francesco, Prince Ruspoli, 3rd Prince of Cerveteri, 3rd Marquis of Riano, 8th Count of Vignanello (February 19, 1752 – March 8, 1829) was the 3rd Prince of Cerveteri, 3rd Marquis of Riano and 8th Count of Vignanello, son of Alessandro Ruspoli, 2nd Prince of Cerveteri and second wife and first cousin Prudenza dei Conti Marescotti-Capizucchi.
His uncle was Bartolomeo Ruspoli.
In 1792 he was created Prince of the Holy Roman Empire both he and his male descendants, by the Emperor Francis II.