Giorgio De Stefano (Italian pronunciation: ['d?ord?o de 'ste?fano]; Reggio Calabria, unknown – Santo Stefano in Aspromonte, November 7, 1977) was an Italian mobster and high-ranking boss of the 'Ndrangheta, a Mafia-type criminal organisation in Calabria (southern Italy).
Together with his brothers Paolo, Giovanni and Orazio he headed the De Stefano 'ndrina.