Mohammed Mahdi Akef (Arabic: ???? ???? ????) (July 12, 1928 – September 22, 2017) was the head of the Muslim Brotherhood, an Egypt-based Islamic political movement, from 2004 until 2010.
He assumed the post, that of "general guide" (Arabic: ?????? ?????) (frequently translated as "chairman") upon the death of his predecessor, Ma'mun al-Hudaybi.
Akef was arrested on 4 July 2013.
On 14 July 2013 Egypt's new prosecutor general Hisham Barakat ordered his assets to be frozen.