(November 4, 1806 – February 23, 1864) was a pioneer Italian Dominican friar and Catholic missionary priest who helped bring the church to the Iowa-Illinois-Wisconsin tri-state area.
He founded a number of parishes in the area, and was the architect for a number of parish buildings.
Additionally, Mazzuchelli founded a number of schools throughout the region, some of which have developed into local Catholic colleges.
As part of this effort, he founded the Sinsinawa Dominican Sisters.