Sophie Hedwig of Saxe-Merseburg (4 August 1660 - 2 August 1686), was a German noblewoman member of the House of Wettin and by marriage Duchess of Saxe-Saalfeld.
Born in Merseburg, she was a child of Christian I, Duke of Saxe-Merseburg and his wife Christiana of Schleswig-Holstein-Sonderburg-Glücksburg.