Léodegario Santa Cruz (born 10 August 1988) is a Mexican professional boxer.
He has held multiple world championships in four weight classes, including the WBA (Super) featherweight title since 2017 and the WBA (Super) super featherweight title since November 2019; previously he held the IBF bantamweight title from 2012 to 2013, the WBC super bantamweight title from 2013 to 2015, and the WBA (Super) featherweight title in his first reign from 2015 to 2016.
As of March 2019, Santa Cruz is ranked as the world's ninth best active boxer, pound for pound, by the Transnational Boxing Rankings Board (TBRB); and tenth by BoxRec.
In January 2018, he reached a peak pound for pound ranking of sixth by the TBRB.
He is also ranked as the world's best active featherweight by The Ring magazine, BoxRec, and the TBRB.