Sancan's Sonatine for flute and piano (1946) is his best-known work, and has been a popular staple for flute players since its publication, but little else of his oeuvre is well known.
Sancan also composed a Violin Concerto, at least three ballets, a Symphony for Strings (1961), and an opera Ondine (1962).
Some of his shorter piano pieces, such as Boîte à musique and the Toccata, have caught on as encore pieces.
Sancan sought to reconcile contemporary performance techniques with the harmonic language of Debussy, a composer of whom Sancan was an expert interpreter.