She subsequently signed a contract with Universal Pictures.
She appeared in over twenty films during the course of her seven-year career, with lead parts in such films as Hold 'Em Yale (1928) and the controversial crime film Party Girl (1930).
She also appeared in the musical King of Jazz (1930) as a vocalist.
Loff formally retired from acting in 1934, with her last screen credit in Joseph Santley's Million Dollar Baby (1934).
She died on August 4, 1942 from ammonia poisoning in Los Angeles at the age of 35.
Though law enforcement was unable to determine whether her death was an accident or a suicide, Loff's family maintained that she had been murdered.