They met in Los Angeles in 1966 and married while she was pregnant with their first child, Moon, followed by Dweezil, Ahmet and Diva.
In 2002, Zappa founded the Zappa Family Trust, a holder for the title and copyright to Frank Zappa's musical and artistic products, as well as his commercial image.
In 2015, the Trust was given to her son Ahmet shortly before she died of lung cancer.