Sophia Eleonore of Hesse-Darmstadt (7 January 1634 in Darmstadt – 7 October 1663 in Bingenheim, now part of Echzell), was Landgravine of Hesse-Darmstadt by birth and by marriage Landgravine of Hesse-Homburg.
She was a daughter of Landgrave George II of Hesse-Darmstadt (1605–1661) from his marriage to Sophia Eleonore (1609–1671), the daughter of Elector John George I of Saxony.