Anna Maria of Mecklenburg-Schwerin (1 July 1627, in Schwerin – 11 December 1669, in Halle) was a German noblewoman, a member of the House of Mecklenburg and by marriage Duchess of Saxe-Weissenfels.
She was the fourth child and second daughter of Adolf Frederick I, Duke of Mecklenburg-Schwerin by his first wife Anna Maria, daughter of Enno III, Count of Ostfriesland.
In older historiography she appears with a third name, Dorothea, but modern historians have discarded it.