She has made major contributions in understanding cancer, endocrinology, and women's health, focusing on nuclear receptors and on improving the effectiveness of endocrine therapies in breast cancer.
Her work has delineated structure-function relationships and mechanisms of action of estrogen receptors alpha and beta.
She has elucidated the molecular basis of action of SERMs such as tamoxifen and raloxifene in treatment and prevention of breast cancer, and she has identified critical aggressiveness factors in breast tumors that promote metastasis and resistance to cancer therapies, and she has studied approaches to inhibit them.