Andrés Grillasca Salas (6 January 1888 - 19 December 1973) was a Puerto Rican farmer from Adjuntas, Puerto Rico, and Mayor of Ponce, Puerto Rico, from 2 January 1941 to 9 May 1956.
Until the 1990s administration of Rafael Cordero Santiago, Grillasca Salas had the distinction of being the longest-serving mayor of the city (16 years).