Anna Megale Komnene (Greek: ???a ?e???? ??ยต????, romanized: Anna Megale Komnene, 6 April 1357 - after 30 November 1406), was a Trapezuntine Queen consort of Georgia as the second wife of King Bagrat V.
She was the mother of his youngest son, Constantine I of Georgia, who would later in 1407 succeed his half-brother, King George VII and reign as king.
She was a member of the powerful Byzantine Greek Komnenos dynasty which was founded by Isaac I Komnenos in 1057.