Anne Cecil, Countess of Oxford (5 December 1556 – 5 June 1588) was the daughter of the statesman William Cecil, 1st Baron Burghley, chief adviser to Queen Elizabeth I of England, and the translator Mildred Cooke.
In 1571 she became the first wife of Edward de Vere, 17th Earl of Oxford.
She served as a Maid of Honour to Queen Elizabeth before her marriage.