Hughes has had various high-profile enterprises including the Anne Hughes Coffee Room at Powell's bookstore, an eponymous art gallery, a bed and breakfast, and the Kitchen Table Cafe.
Mentioned along with Matt Groening, Paul Allen, and Phil Knight, she was described as a "One-Woman KaffeeKlatsch" by Willamette Week as part of the weekly's 25th anniversary celebration in "They Rule: Some of our Favorite Portlanders".