Marios Matsakis (born 2 August 1954) is a Cypriot medical doctor, forensic pathologist, coroner, and politician who served as Member of the European Parliament and Member of the House of Representatives for the Democratic Party.
In the European Parliament he sat with the Alliance of Liberals and Democrats for Europe group.
He became involved in politics in the mid-1990s and has sparked controversy on several occasions.
He announced on 29 December 2007 that he would run for president in the 2008 Cypriot presidential elections.
He gained 0.77% of the national vote, coming fourth behind the three main candidates.