She had a troubled childhood, but was rescued by the older novelist Doris Lessing; she lived in Lessing's house for four years.
Diski was educated at University College London, and worked as a teacher during the 1970s and early 1980s.Diski was a regular contributor to the London Review of Books; the collections Don't and A View from the Bed include articles and essays written for the publication.
She won the 2003 Thomas Cook Travel Book Award for Stranger on a Train: Daydreaming and Smoking around America With Interruptions.