Sehzade Burhaneddin Cem (2 February 1920 – 31 October 2008) was the heir apparent to the headship of the Ottoman dynasty.
He was born at Besiktas, Istanbul as the son of Prince Ibrahim Tevfik (1874–1931) and his fourth wife Hatice Sadiye Hanim (1898–1986).
Burhaneddin was a descendant of Sultan Abdülmecid I.
He married Irene Starosselskaya of Russian–Georgian noble descent (born 1928) and had two children, Nilüfer Sultan (born 1953) and Sehzade Selim (1955).