Charlotte Lee, Lady Baltimore (13 March 1678 Old Style – 22 January 1721 Old Style), was an English noblewoman, and granddaughter of King Charles II of England and his mistress Barbara Villiers.
She married in 1699, Benedict Leonard Calvert, 4th Baron Baltimore, from whom she separated in 1705; she later married Christopher Crowe.
She was the mother of Charles Calvert, 5th Baron Baltimore, and of Benedict Leonard Calvert, who was Governor of Maryland from 1727–1731.