Chief Mbuso Alphin Mqalo (10 October 1916 – 1 August 2008) was the chief of the Amakhuze Tribe in Alice, South Africa and the oldest chief of the Rharhabe Kingdom.
His reign was from the early 1960s to 2006.
In 1973, he became a member of the Ciskei National Assembly (Parliament) as a member of the ruling party, the Ciskei National Independent Party (CNIP).
On the 17 May 1976, he became a member of the Ciskei cabinet for the position of Minister of Justice.
In 1977, he was elected to Minister of Health and after 1978, when Ciskei became a one-party state, he became the Whip of the CNIP.
During his term as Minister of Health he was prominent in the renaming of the Mdantsane Hospital to the Cecilia Makiwane Hospital, to commemorate Cecilia Makiwane, the first Black nurse in South Africa.