Clayton Hamilton (born June 15, 1982) is a retired American pitcher for the Yokohama DeNA BayStars.
From Penn State University, he was selected by the San Diego Padres in the 17th Round (492nd overall) of the 2004 amateur entry draft.
He was signed by scout Josh Boyd.
On December 8, 2005, he was sent by the San Diego Padres to the Pittsburgh Pirates as a player to be named later in a November 21, 2005 trade.
On December 6, 2007, he was picked up in the Minor League phase of the Rule 5 Draft by the Texas Rangers.
Hamilton split 2008 between the Bakersfield Blaze and Frisco RoughRiders.
In 2009, he worked with Frisco and the Oklahoma City RedHawks.
In 2005 Hamilton won the Fort Wayne Wizards' "Pitcher/Prospect of the Year" award, and was selected for the Eastern Division's All-Star team.