Clinton O'Brien (born 10 January 1974) is an Australian former professional rugby league footballer who played in the 1990s and 2000s.
A Queensland State of Origin representative forward, he played club football in Australia for the Sydney Roosters, South Queensland Crushers, Gold Coast Chargers and Newcastle Knights (with whom he won the 2001 NRL premiership), as well as English club Wakefield Trinity Wildcats.
O'Brein represented Queensland in the 1997 State of Origin series.