Princess Luise of Anhalt-Bernburg (30 October 1799, Ballenstedt – 9 December 1882, Eller, Düsseldorf) was a German Princess.
As the daughter of Alexius Frederick Christian, Duke of Anhalt-Bernburg and his wife Marie Friederike of Hesse-Kassel, she was a Princess of Anhalt-Bernburg and member of the House of Ascania.
By her 21 November 1817 marriage to Prince Frederick of Prussia she was a princess of Prussia.
She had two children: Prince Alexander of Prussia (21 June 1820, Berlin – 4 January 1896, Berlin) and Prince George of Prussia (12 February 1826, Düsseldorf – 2 May 1902, Berlin).