Diane Van Deren (born February 20, 1960) is an American ultra-runner who won the Yukon Arctic Ultra 300 in 2009.
Van Deren had a lobectomy in 1997.
She competed in races of attrition measuring 100 miles or more.
She was the first woman to complete the 430-mile Yukon Arctic Ultra 300.
A former professional tennis player, she took up running to help stave off epileptic seizures, for which in 1997 she had a lobectomy.
This surgery disrupted her ability to judge the passing of time, something which has helped her ultra-running.
She was featured in the 2012 CBC documentary The Perfect Runner, directed by documentary filmmaker Niobe Thompson for The Nature of Things.